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CEBPD

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Identifiers
SymbolsCEBPD ; C/EBP-delta; CELF; CRP3; NF-IL6-beta
External IDsOMIM116898 MGI103573 HomoloGene3808 GeneCards: CEBPD Gene
Orthologs
SpeciesHumanMouse
Entrez105212609
EnsemblENSG00000221869n/a
UniProtP49716Q00322
RefSeq (mRNA)NM_005195NM_007679
RefSeq (protein)NP_005186NP_031705
Location (UCSC)Chr 8:
48.65 – 48.65 Mb
n/a
PubMed search[1][2]

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. [4]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. [5]


Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[6]

See also

References

  1. ^ Cao Z, Umek RM, McKnight SL (October 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538. 
  2. ^ Williams SC, Cantwell CA, Johnson PF (October 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553. 
  3. ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". 
  4. ^ Gery s (2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. PMID 15674331. doi:10.1038/sj.onc.1208393. 
  5. ^ Duitman J (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Lab Invest. 94 (1): 89–97. PMID 24247561. doi:10.1038/labinvest.2013.127. 
  6. ^ Choy, Lisa; Derynck Rik (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". J. Biol. Chem. (United States) 278 (11): 9609–19. ISSN 0021-9258. PMID 12524424. doi:10.1074/jbc.M212259200. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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