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Open Access Articles- Top Results for CEBPE

CEBPE

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Identifiers
SymbolsCEBPE ; C/EBP-epsilon; CRP1
External IDsOMIM600749 MGI103572 HomoloGene1367 GeneCards: CEBPE Gene
RNA expression pattern
File:PBB GE CEBPE 214523 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1053110794
EnsemblENSG00000092067ENSMUSG00000052435
UniProtQ15744Q6PZD9
RefSeq (mRNA)NM_001805NM_207131
RefSeq (protein)NP_001796NP_997014
Location (UCSC)Chr 14:
23.59 – 23.59 Mb
Chr 14:
54.71 – 54.71 Mb
PubMed search[1][2]

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[1][2] and is pro-apoptotic.[3]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[1]

References

  1. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". 
  2. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (July 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. PMID 8661101. doi:10.1006/geno.1996.0319. 
  3. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". J. Biol. Chem. 281 (20): 14494–502. PMID 16531405. doi:10.1074/jbc.M600575200. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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