Open Access Articles- Top Results for CELSR1


SymbolsCELSR1 ; CDHF9; FMI2; HFMI2; ME2
External IDsOMIM604523 MGI1100883 HomoloGene7665 IUPHAR: 178 GeneCards: CELSR1 Gene
RNA expression pattern
File:PBB GE CELSR1 41660 at tn.png
File:PBB GE CELSR1 204539 s at tn.png
File:PBB GE CELSR1 217262 s at tn.png
More reference expression data
RefSeq (mRNA)NM_014246NM_009886
RefSeq (protein)NP_055061NP_034016
Location (UCSC)Chr 22:
46.76 – 46.93 Mb
Chr 15:
85.9 – 86.03 Mb
PubMed search[1][2]

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.[1][2]


The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[2]

See also


  1. ^ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics 45 (1): 97–104. PMID 9339365. doi:10.1006/geno.1997.4892. 
  2. ^ a b "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". 

Further reading


Lua error in package.lua at line 80: module 'Module:Buffer' not found. This article incorporates text from the United States National Library of Medicine, which is in the public domain.