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Open Access Articles- Top Results for CELSR2

CELSR2

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsCELSR2 ; CDHF10; EGFL2; Flamingo1; MEGF3
External IDsOMIM604265 MGI1858235 HomoloGene1078 IUPHAR: 179 GeneCards: CELSR2 Gene
RNA expression pattern
File:PBB GE CELSR2 204029 at tn.png
File:PBB GE CELSR2 36499 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez195253883
EnsemblENSG00000143126ENSMUSG00000068740
UniProtQ9HCU4A2AEE7
RefSeq (mRNA)NM_001408NM_001004177
RefSeq (protein)NP_001399NP_001004177
Location (UCSC)Chr 1:
109.79 – 109.82 Mb
Chr 3:
108.39 – 108.42 Mb
PubMed search[1][2]

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[2]

See also

References

  1. ^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics 51 (1): 27–34. PMID 9693030. doi:10.1006/geno.1998.5341. 
  2. ^ a b "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)". 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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