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Open Access Articles- Top Results for CELSR3

CELSR3

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Identifiers
SymbolsCELSR3 ; CDHF11; EGFL1; FMI1; HFMI1; MEGF2; RESDA1
External IDsOMIM604264 MGI1858236 HomoloGene1077 IUPHAR: 180 GeneCards: CELSR3 Gene
Orthologs
SpeciesHumanMouse
Entrez1951107934
EnsemblENSG00000008300ENSMUSG00000023473
UniProtQ9NYQ7Q91ZI0
RefSeq (mRNA)NM_001407NM_080437
RefSeq (protein)NP_001398NP_536685
Location (UCSC)Chr 3:
48.64 – 48.66 Mb
Chr 9:
108.83 – 108.85 Mb
PubMed search[1][2]

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[2]

See also

References

  1. ^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics 51 (1): 27–34. PMID 9693030. doi:10.1006/geno.1998.5341. 
  2. ^ a b "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)". 

Further reading

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