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Open Access Articles- Top Results for CERC-301

CERC-301

CERC-301
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IUPAC name
4-Methylbenzyl (3S,4R)-3-fluoro-4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate
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ChemSpider 9569140
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C19H23FN4O2
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

CERC-301 (formerly known as MK-0657) is an orally-active, selective NMDA receptor subunit 2B (NR2B) antagonist which is under development by Cerecor in the United States as an adjunctive therapy for treatment-resistant depression (TRD).[1] In November 2013, phase II clinical trials were initiated,[2] and in the same month, CERC-301 received Fast Track Designation from the Food and Drug Administration for TRD.[3]

A pilot study was published in 2012,[1] and a phase 2 trial was completed in 2014.[4]

See also

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