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Open Access Articles- Top Results for CGS-21680

CGS-21680

CGS-21680
200px
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IUPAC name
3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Other names
CGS 21680
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120225-54-9 7pxY
ChEBI CHEBI:73283 7pxN
ChEMBL ChEMBL331372 7pxY
ChemSpider 2343185 7pxN
IUPHAR ligand 375
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C23H29N7O6
Molar mass 499.52
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

See also

References

  • Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol 100 (1): 91–97. PMID 16141383. doi:10.1152/japplphysiol.00459.2005. 
  • Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater 15 (2-3): 225–228. doi:10.1016/j.diamond.2005.08.018. 



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