Open Access Articles- Top Results for CGS-9896


Systematic (IUPAC) name
Clinical data
77779-36-3 7pxY
PubChem CID 108030
ChemSpider 97139 7pxN
Chemical data
Formula C16H10ClN3O
295.7231 g/mol
 14pxN (what is this?)  (verify)

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]


  1. Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. PMID 2854261. doi:10.1016/0091-3057(88)90342-5. 
  2. Bernasconi R, Marescaux C, Vergnes M et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. PMID 3343593. doi:10.1007/BF01259406. 
  3. Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch Toxicol. 64 (5): 412–3. PMID 2206111. doi:10.1007/BF01973465. 
  4. Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. PMID 7667375. doi:10.1016/0091-3057(95)00020-W. 
  5. Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. PMID 2109664. doi:10.1111/j.1440-1681.1990.tb01298.x. 

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