Chloride channel, calcium activated, family member 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel. This protein is not expressed in humans but is in certain other species such as mouse.
This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.
- Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl− channels". Biochim. Biophys. Acta 1444 (3): 418–23. PMID 10095065. doi:10.1016/S0167-4781(99)00008-1.
- "Entrez Gene: chloride channel accessory 3 (pseudogene)".
- Pawłowski K, Lepistö M, Meinander N et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. PMID 16470849. doi:10.1002/prot.20887.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Liu QH, Williams DA, McManus C et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. PMC 18318. PMID 10758170. doi:10.1073/pnas.090521697.
- Pauli BU, Abdel-Ghany M, Cheng HC et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. PMID 11071307. doi:10.1046/j.1440-1681.2000.03358.x.
- Gruber AD, Pauli BU (1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31).". Genome 42 (5): 1030–2. PMID 10584316. doi:10.1139/gen-42-5-1030.