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CLCA3

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Identifiers
SymbolsCLCA3P ; CLCA3
External IDsOMIM604337 GeneCards: CLCA3P Gene
Orthologs
SpeciesHumanMouse
Entrez962923844
EnsemblENSG00000153923ENSMUSG00000028255
UniProtQ9Y6N3Q9D7Z6
RefSeq (mRNA)NM_004921NM_017474
RefSeq (protein)n/aNP_059502
Location (UCSC)Chr 1:
87.1 – 87.12 Mb
Chr 3:
144.67 – 144.7 Mb
PubMed search[1][2]

Chloride channel, calcium activated, family member 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[1] This protein is not expressed in humans but is in certain other species such as mouse.

Function

This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding.[2] Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[3]

See also

References

  1. ^ Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl channels". Biochim. Biophys. Acta 1444 (3): 418–23. PMID 10095065. doi:10.1016/S0167-4781(99)00008-1. 
  2. ^ "Entrez Gene: chloride channel accessory 3 (pseudogene)". 
  3. ^ Pawłowski K, Lepistö M, Meinander N et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. PMID 16470849. doi:10.1002/prot.20887. 

Further reading

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External links

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