Adverts

Open Access Articles- Top Results for CLEC4M

CLEC4M

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsCLEC4M ; CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
External IDsOMIM605872 MGI2157947 HomoloGene129771 GeneCards: CLEC4M Gene
RNA expression pattern
File:PBB GE CLEC4M 207995 s at tn.png
File:PBB GE CLEC4M 210481 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez10332170786
EnsemblENSG00000104938ENSMUSG00000031494
UniProtQ9H2X3Q91ZX1
RefSeq (mRNA)NM_001144904NM_133238
RefSeq (protein)NP_001138376NP_573501
Location (UCSC)Chr 19:
7.83 – 7.83 Mb
Chr 8:
3.74 – 3.75 Mb
PubMed search[1][2]

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.[1] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[2]

References

  1. ^ Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene 228 (1-2): 161–7. PMID 10072769. doi:10.1016/S0378-1119(99)00004-9. 
  2. ^ "Entrez Gene: CLEC4M C-type lectin domain family 4, member M". 

Further reading

</dl>

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found. This article incorporates text from the United States National Library of Medicine, which is in the public domain.