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Open Access Articles- Top Results for COL24A1

COL24A1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolCOL24A1
External IDsOMIM610025 HomoloGene65061 GeneCards: COL24A1 Gene
Orthologs
SpeciesHumanMouse
Entrez25563171355
EnsemblENSG00000171502ENSMUSG00000028197
UniProtQ17RW2Q30D77
RefSeq (mRNA)NM_152890NM_027770
RefSeq (protein)NP_690850NP_082046
Location (UCSC)Chr 1:
85.73 – 86.16 Mb
Chr 3:
145.29 – 145.55 Mb
PubMed search[1][2]

Collagen, type XXIV, alpha 1 is a protein that in humans is encoded by the COL24A1 gene.[1]

Model organisms

Model organisms have been used in the study of COL24A1 function. A conditional knockout mouse line called Col24a1tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute [2]. Male and female animals underwent a standardized phenotypic screen[3] to determine the effects of deletion.[4][5][6][7] Additional screens performed: - In-depth immunological phenotyping[8] - in-depth bone and cartilage phenotyping[9]

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References

  1. ^ "Entrez Gene: Collagen, type XXIV, alpha 1". 
  2. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  3. ^ a b "International Mouse Phenotyping Consortium". 
  4. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  5. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  6. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  7. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  8. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 
  9. ^ a b "OBCD Consortium".