Open Access Articles- Top Results for COUP-TFII


External IDsOMIM107773 MGI1352452 HomoloGene7628 IUPHAR: 618 GeneCards: NR2F2 Gene
RNA expression pattern
File:PBB GE NR2F2 209120 at tn.png
File:PBB GE NR2F2 209121 x at tn.png
File:PBB GE NR2F2 215073 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001145155NM_009697
RefSeq (protein)NP_001138627NP_033827
Location (UCSC)Chr 15:
96.87 – 96.88 Mb
Chr 7:
70.35 – 70.37 Mb
PubMed search[1][2]

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.[1][2] The COUP acronym stands for chicken ovalbumin upstream promoter.


COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.[3][4]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.[5][6] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.[7]


COUP-TFII has been shown to interact with:


  1. "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2". 
  2. Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L et al. (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. PMID 8530078. doi:10.1006/geno.1995.1237. 
  3. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. PMC 316637. PMID 10215630. doi:10.1101/gad.13.8.1037. 
  4. Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ et al. (December 2004). "The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development". Mol. Cell. Biol. 24 (24): 10835–43. PMC 533959. PMID 15572686. doi:10.1128/MCB.24.24.10835-10843.2004. 
  5. De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. PMID 14739255. doi:10.1210/me.2003-0341. 
  6. De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. PMID 15265774. doi:10.1196/annals.1321.006. 
  7. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. PMC 2268152. PMID 18250317. doi:10.1073/pnas.0707082105. 
  8. Smirnov DA, Hou S, Ricciardi RP (March 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. PMID 10704340. doi:10.1006/viro.1999.0181. 
  9. Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (November 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. PMID 8910285. doi:10.1074/jbc.271.44.27197. 
  10. Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P et al. (May 1999). "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. PMC 2823254. PMID 10318855. doi:10.1074/jbc.274.20.14331. 
  11. Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J et al. (May 2012). "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.". PLoS One 7 (5). PMC 3365040. PMID 22693611. doi:10.1371/journal.pone.0038278. 

Further reading