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Open Access Articles- Top Results for CP-132,484

CP-132,484

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CP-132,484
140px
Systematic (IUPAC) name
1-(2-aminoethyl)-3-methyl-8,9-dihydropyrano(3,2-e)indole
Clinical data
Identifiers
143508-76-3 7pxN
PubChem CID 132564
Chemical data
Formula C14H18N2O
230.305 g/mol

CP-132,484 is a tryptamine derivative which acts as a potent and selective agonist for the 5-HT2 family of serotonin receptors.[1] It has reasonable selectivity for 5-HT2A and 5-HT2C subtypes over 5-HT2B, but is only slightly selective for 5-HT2A over 5-HT2C. This compound and several related analogues have been shown to have ocular hypotensive activity in animal models, suggesting they may be useful for the treament of glaucoma.[2]

See also

References

  1. Macor JE, Fox CB, Johnson C, Koe BK, Lebel LA, Zorn SH. 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. Journal of Medicinal Chemistry. 1992 Oct 2;35(20):3625-32. PMID 1433172
  2. May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95. PMID 12954071. doi:10.1021/jm030205t. 


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