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Open Access Articles- Top Results for CXCR5

CXCR5

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Identifiers
SymbolsCXCR5 ; BLR1; CD185; MDR15
External IDsOMIM601613 MGI103567 HomoloGene1298 IUPHAR: 72 ChEMBL: 1075315 GeneCards: CXCR5 Gene
RNA expression pattern
File:PBB GE BLR1 206126 at tn.png
File:PBB GE BLR1 216734 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez64312145
EnsemblENSG00000160683ENSMUSG00000047880
UniProtP32302Q04683
RefSeq (mRNA)NM_001716NM_007551
RefSeq (protein)NP_001707NP_031577
Location (UCSC)Chr 11:
118.75 – 118.77 Mb
Chr 9:
44.51 – 44.56 Mb
PubMed search[1][2]

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.[1]

Tissue distribution and function

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.[2]

References

  1. ^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". Eur. J. Immunol. 22 (11): 2795–9. PMID 1425907. doi:10.1002/eji.1830221107. 
  2. ^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell 87 (6): 1037–47. PMID 8978608. doi:10.1016/S0092-8674(00)81798-5. 


Further reading

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