Open Access Articles- Top Results for CY-208,243


File:CY-208,243 structure.png
Systematic (IUPAC) name
Clinical data
100999-26-6 7pxY
PubChem CID 58144
ChemSpider 52380 7pxN
Chemical data
Formula C19H18N2
274.359 g/mol
 14pxN (what is this?)  (verify)

CY-208,243 is a drug which acts as a dopamine agonist selective for the D1 subtype. Unlike most D1-selective agonists, it shows efficacy in animal models of Parkinson's disease.[1][2][3][4][5]


  1. ^ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064. doi:10.1016/0278-5846(95)00110-h. 
  2. ^ Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology 6 (8): 785–793. PMID 11224381. doi:10.1097/00008877-199512000-00003. 
  3. ^ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology 69: 239–44. PMID 8615134. 
  4. ^ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology 460 (1): 71–4. PMID 12535862. doi:10.1016/S0014-2999(02)02881-9. 
  5. ^ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research 156 (2): 173–9. PMID 15582103. doi:10.1016/j.bbr.2004.05.019. 

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