Caenorhabditis briggsae is a small nematode, closely related to Caenorhabditis elegans. The differences between the two species are subtle. The male tail in C. briggsae has a slightly different morphology from C. elegans. Other differences include changes in vulval precursor competence and the placement of the excretory duct opening. C. briggsae is frequently used to study the differences between it and the more intimately understood C. elegans, especially at the DNA and protein sequence level. Several mutant strains of C. briggsae have also been isolated that facilitate genetic analysis of this organism. C. briggsae, like C. elegans, is a hermaphrodite. The genome sequence for C. briggsae was determined in 2003.
Ellsworth C. Dougherty first recognized the potential of C. briggsae, which had been found by Margaret Briggs in a pile of leaves on the campus of Stanford University in Palo Alto, California, in 1944, and used in her MS studies under the direction of Dr. Arthur C. Giese. Briggs studied the lifecycle of what she identified as a Rhabditis species in association with bacteria and in various culture media devoid of other organisms. She showed the population could not be sustained in the absence of bacteria or even on dead bacterial cells; living bacteria were a necessary food source. However, survival of individuals was greater on some bacteria-free media than others. 
C. briggsae can often be found in compost, garden beds, moist mushrooms, or rotting fruit rich with microorganisms and various nutrients. The organism's main habitat is often considered to be the temperate regions of the globe, often accompanying its relatives C. elegans and C. remanei.
Overview of genome
The genome of C. briggsae is roughly 100 Mb in size and is predicted to encode about 20,000 genes. The whole genome sequencing project revealed the genomes of C. briggsae and C. elegans to have much in common. For example, both worms have the same number of chromosomes (six), similar genome size, and similar numbers of protein coding and nonprotein coding genes. Further analysis demonstrated about 62% of the protein-coding genes in C. briggsae have orthologs in C. elegans. Nevertheless, many interesting species-specific features including genes exist, which serve as the foundation for comparative analysis.
Comparative genomics with C. elegans
C. briggsae is a soil nematode estimated to have diverged from C. elegans around 80–100 million years ago, and yet is morphologically almost indistinguishable from it. Areas of sequence-encoding proteins are mostly conserved between the two species, while most intergenic and intronic sequences are divergent. Areas of similarity between the sequences of the two organisms can suggest coding exons or point to regulatory regions and to RNA genes missed in standard analysis.
- Gupta, B. P. and Sternberg, P. W. (2003). "The draft genome sequence of the nematode Caenorhabditis briggsae, a companion to C. elegans". Genome Biology 4 (12): 238. PMC 329410. PMID 14659008. doi:10.1186/gb-2003-4-12-238.
- Nematode C. briggsae Research Resource
- Haag, Eric S. "The evolution of nematode sex determination: C. elegans as a reference point for comparative biology". WormBook.
- Stein; L. D. et al. (2003). "The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics". PLoS Biology 1 (2): 166–192. PMC 261899. PMID 14624247. doi:10.1371/journal.pbio.0000045.
- Briggs, 1946; Gochnauer, 2004
- Ellsworth C Dougherty
- Watson L. D. et al. (2007). "Caenorhabditis briggsae". Washington University in St. Louis.
- Stein et al., 2003
- Genomics and biology of the nematode Caenorhabditis briggsae
- C. briggsae Project