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Calcitroic acid

Calcitroic acid
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IUPAC name
(3R)-3-[(1R,3aR,4E,7aR)- 4-[(2Z)-2-[(3R,5R)-3,5- Dihydroxy-2-methylene-cyclohexylidene]ethylidene] -7a-methyl-2,3,3a,5,6,7-hexahydro-1H -inden-1-yl]butanoic acid
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71204-89-2
ChemSpider 4947800
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C23H34O4
Molar mass 374.514
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Calcitroic acid (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3) is a metabolite of 1α,25-dihydroxyvitamin D3 (calcitriol). Its formation is catalyzed by the enzyme calcitriol 24-hydroxylase.[1] Calcitroic acid is soluble in water and excreted in bile.[2]

References

  1. ^ Sakaki T, Kagawa N, Yamamoto K, Inouye K (January 2005). "Metabolism of vitamin D3 by cytochromes P450". Front. Biosci. 10: 119–34. PMID 15574355. 
  2. ^ Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. Modern nutrition in health and disease. 11. ed, Baltimore: Lippincott Williams & Wilkins 2014.


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