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Camphor

For other uses, see Camphor (disambiguation).
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Camphor[1][2]

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IUPAC name
1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
Systematic IUPAC name
1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
Other names
2-Bornanone; Bornan-2-one; 2-Camphanone; Formosa
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3DMet B04729 ATC code C01EB02 1907611 76-22-2 7pxY
21368-68-3 7pxN
464-49-3 (R) 7pxN
464-48-2 (S) 7pxN ChEBI CHEBI:36773 7pxY ChEMBL ChEMBL504760 7pxN ChemSpider 2441 7pxY
7822160 (R) 7pxY
9655 (S) 7pxY DrugBank DB01744 7pxY EC number 200-945-0 83275 IUPHAR ligand 2422 Jmol-3D images Image
Image KEGG D00098 7pxY MeSH Camphor PubChem Template:Chembox PubChem/formatTemplate:Chembox PubChem/formatTemplate:Chembox PubChem/format RTECS number EX1225000 Template:Chembox UNII UN number 2717 colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
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This page is a soft redirect.- C10H16O Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1 Appearance White, translucent crystals Odor fragrant and penetrating Density 0.992 g cm−3 Melting point Script error: No such module "convert". Boiling point Script error: No such module "convert". 1.2 g dm−3 Solubility in acetone ~2500 g dm−3 Solubility in acetic acid ~2000 g dm−3 Solubility in diethyl ether ~2000 g dm−3 Solubility in chloroform ~1000 g dm−3 Solubility in ethanol ~1000 g dm−3 log P 2.089 Vapor pressure 4 mmHg (at 70 °C) +44.1° colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
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EU classification Highly Flammable FHarmful Xn R-phrases R11 R22 R36/37/38 S-phrases S16 S26 NFPA 704

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Flash point Script error: No such module "convert". Script error: No such module "convert". Explosive limits 0.6%-3.5%[3] 1310 mg/kg (oral, mouse)[4] US health exposure limits (NIOSH):

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Related Ketones
Fenchone, Thujone
Related compounds
Camphene, Pinene, Borneol, Isoborneol, Camphorsulfonic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Camphor (/ˈkæmfər/) is a waxy, flammable, white or transparent solid with a strong aromatic odor.[5] It is a terpenoid with the chemical formula C10H16O. It is found in the wood of the camphor laurel (Cinnamomum camphora), a large evergreen tree found in Asia (particularly in Sumatra, Indonesia and Borneo ) and also of the unrelated kapur tree, a tall timber tree from the same region. It also occurs in some other related trees in the laurel family, notably Ocotea usambarensis. Dried rosemary leaves (Rosmarinus officinalis), in the mint family, contain up to 20% camphor. Camphor can also be synthetically produced from oil of turpentine. It is used for its scent, as an ingredient in cooking (mainly in India), as an embalming fluid, for medicinal purposes, and in religious ceremonies. A major source of camphor in Asia is camphor basil.

Norcamphor is a camphor derivative with the three methyl groups replaced by hydrogen.

Etymology

The word camphor derives from the French word camphre, itself from Medieval Latin camfora, from Arabic kafur, from Sanskrit, कर्तूर / karpūra.[6] The term ultimately was derived from Old Malay kapur barus which means "the chalk of Barus". Barus was the name of an ancient port located near modern Sibolga city on the western coast of Sumatra island (today North Sumatra Province, Indonesia).[citation needed] This port was initially built prior to the Indian–Batak trade in camphor and spices. Traders from India, East Asia and the Middle East would use the term kapur barus to buy the dried extracted ooze of camphor trees from local Batak tribesmen; the camphor tree itself is natively found in that region. In the proto-Malay-Austronesian language, it is also known as kapur Barus. Even now, the local tribespeople and Indonesians in general refer to naphthalene balls and moth balls as kapur Barus.

Production

File:Sublimed camphor.jpg
A sample of sublimed camphor

In the 19th century, it was known that with nitric acid, camphor could be oxidized into camphoric acid. Haller and Blanc published a semisynthesis of camphor from camphoric acid, which, although demonstrating its structure, would not prove it. The first complete total synthesis for camphoric acid was published by Gustaf Komppa in 1903. Its starting materials were diethyl oxalate and 3,3-dimethylpentanoic acid, which reacted by Claisen condensation to give diketocamphoric acid. Methylation with methyl iodide and a complicated reduction procedure produced camphoric acid. William Perkin published another synthesis a short time later. Previously, some organic compounds (such as urea) had been synthesized in the laboratory as a proof of concept, but camphor was a scarce natural product with a worldwide demand. Komppa realized this and began industrial production of camphor in Tainionkoski, Finland, in 1907.

Camphor can be produced from alpha-pinene, which is abundant in the oils of coniferous trees and can be distilled from turpentine produced as a side product of chemical pulping. With acetic acid as the solvent and with catalysis by a strong acid, alpha-pinene readily rearranges into camphene, which in turn undergoes Wagner-Meerwein rearrangement into the isobornyl cation, which is captured by acetate to give isobornyl acetate. Hydrolysis into isoborneol followed by oxidation gives racemic camphor. By contrast, camphor occurs naturally as D-camphor, the (R)-enantiomer.

Biosynthesis

In biosynthesis, camphor is produced from geranyl pyrophosphate, via cyclisation of linaloyl pyrophosphate to bornyl pyrophosphate, followed by hydrolysis to borneol and oxidation to camphor.

Reactions

Typical camphor reactions are

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Camphor can also be reduced to isoborneol using sodium borohydride.

In 1998, K. Chakrabarti and coworkers from the Indian Association for the Cultivation of Science, Kolkata, prepared diamond thin film using camphor as the precursor for chemical vapor deposition.[7]

In 2007, carbon nanotubes were successfully synthesized using camphor in chemical vapor deposition process.[8]

Uses

The sublimating capability of camphor gives it several uses.

Explosives

Camphor is used as a plasticizer for nitrocellulose, and ingredient for fireworks and explosive munitions.

Pest Deterrent and preservative

Camphor is believed to be toxic to insects and is thus sometimes used as a repellent.[9] Camphor is used to make mothballs. Camphor crystals are sometimes used to prevent damage to insect collections by other small insects. Some folk remedies state camphor will deter snakes and other reptiles due to its strong odor.[citation needed] It is kept in clothes used on special occasions and festivals, and also in cupboard corners as a cockroach repellent.

Camphor is also used as an antimicrobial substance. In embalming, Camphor oil was one of the ingredients used by ancient Egyptians for mummification.[10]

Solid camphor releases fumes that form a rust-preventative coating and is therefore stored in tool chests to protect tools against rust.[11]

Culinary

In ancient and medieval Europe, camphor was used as an ingredient in sweets. It was used in a wide variety of both savory and sweet dishes in medieval Arabic language cookbooks, such as al-Kitab al-Ṭabikh compiled by ibn Sayyâr al-Warrâq in the 10th century,[12] and an anonymous Andalusian cookbook of the 13th century.[13] It also appears in sweet and savory dishes in a book written in the late 15th century for the sultans of Mandu, the Ni'matnama.[14] An early international trade in it made camphor widely known throughout Arabia in pre-Islamic times, as it is mentioned in the Quran 76:5 as a flavoring for drinks.[15] By the 13th century, it was used in recipes everywhere in the Muslim world, ranging from main dishes such as tharid and stew to desserts.[13]

Currently, camphor is used as a flavoring, mostly for sweets, in Asia. It is widely used in cooking, mainly for dessert dishes, in India where it is known as kachha karpooram or "pachha karpoora" ("crude/raw camphor"), in (Telugu:పచ్చ కర్పూరo), (Tamil:பச்சைக் கற்பூரம்), (Kannada:ಪಚ್ಚ ಕರ್ಪೂರ), and is available in Indian grocery stores where it is labeled as "edible camphor".

Medicinal

Camphor is readily absorbed through the skin producing either a coolness or warmth sensation,[16][17] and acts as slight local anesthetic and antimicrobial substance. There are anti-itch gels and cooling gels with camphor as the active ingredient.[citation needed] It is used carefully and in low dosage in baby oil for its calming effects.[citation needed]

Camphor is an active ingredient (along with menthol) in vapor-steam products, such as Vicks VapoRub. It is used as a cough suppressant[citation needed] and as a decongestant[citation needed]. It is also used for aromatherapy.[citation needed]

Camphor may also be administered orally in small quantities (50 mg) for minor heart symptoms and fatigue.[18] Through much of the 1900s this was sold under the trade name Musterole; production ceased in the 1990s.

Camphor was used in ancient Sumatra to treat sprains, swellings, and inflammation.[19] Camphor is a component of paregoric, an opium/camphor tincture from the 18th century. Also in the 18th century, camphor was used by Auenbrugger in the treatment of mania.[20] Based on Hahnemann's writings, camphor (dissolved in alcohol) was also successfully used to treat the 1854-1855 cholera epidemics in Naples.[21]

Regulation

In 1980, the U.S. Food and Drug Administration set a limit of 11% allowable camphor in consumer products, and totally banned products labeled as camphorated oil, camphor oil, camphor liniment, and camphorated liniment (except "white camphor essential oil", which contains no significant amount of camphor). Since alternative treatments exist, medicinal use of camphor is discouraged by the FDA, except for skin-related uses, such as medicated powders, which contain only small amounts of camphor.

Effects on the body

Small dose

Its effects on the body include tachycardia, vasodilation in skin (flushing), slower breathing, reduced appetite, increased secretions and excretions such as perspiration, diuretic. [22]

The sensation of heat or cold that camphor produces is caused by activating the ion channel TRPV3.[23][24]

Large Dose Toxicity

Camphor is poisonous in large doses. It produces symptoms of irritability, disorientation, lethargy, muscle spasms, vomiting, abdominal cramps, convulsions, and seizures.[25][26][27] Lethal doses in adults are in the range 50–500 mg/kg (orally). Generally, two grams cause serious toxicity and four grams are potentially lethal.[28]

Hindu religious ceremonies

Camphor is widely used in Hindu religious ceremonies. Hindus worship a holy flame by burning camphor, which forms an important part of many religious ceremonies. Camphor is used in the Mahashivratri celebrations of Shiva, the Hindu god of destruction and (re)creation. As a natural pitch substance, it burns cool without leaving an ash residue, which symbolizes consciousness. Most temples in southern India have stopped lighting [[Paraffin wax ]] camphor in the main sanctum sanctorum because of the heavy carbon deposits it produces; however, open areas still burn it.[citation needed]

In Gujarat, Tamil Nadu, Andhra Pradesh, Madhya Pradesh, Maharashtra, Karnataka, Kerala & Andamans, camphor is the primary ingredient in any holy ritual. At the end of a holy ritual, camphor flame (called aarti) is burned for the deities.[citation needed]

In some Hindu puja ceremonies, camphor is burned in a ceremonial plate for performing aarti. This type of camphor, the processed white crystalline Paraffin wax kind, is sold at Indian grocery stores.[citation needed]


See also

References

  1. ^ The Merck Index, 7th edition, Merck & Co., Rahway, New Jersey, USA, 1960
  2. ^ Handbook of Chemistry and Physics, CRC Press, Ann Arbor, Michigan, USA
  3. ^ a b c d "NIOSH Pocket Guide to Chemical Hazards #0096". National Institute for Occupational Safety and Health (NIOSH). 
  4. ^ "Camphor (synthetic)". National Institute for Occupational Safety and Health (NIOSH). 4 December 2014. Retrieved 19 February 2015. 
  5. ^ Mann JC, Hobbs JB, Banthorpe DV, Harborne JB (1994). Natural products: their chemistry and biological significance. Harlow, Essex, England: Longman Scientific & Technical. pp. 309–11. ISBN 0-582-06009-5. 
  6. ^ Camphor at the Online Etymology Dictionary
  7. ^ Chakrabarti K,Chakrabarti R, Chattopadhyay KK, Chaudhuri S, Pal AK (1998). "Nano-diamond films produced from CVD of camphor". Diam Relat Mater 7 (6): 845–52. Bibcode:1998DRM.....7..845C. doi:10.1016/S0925-9635(97)00312-9. 
  8. ^ Kumar M, Ando Y (2007). "Carbon Nanotubes from Camphor: An Environment-Friendly Nanotechnology". J Phys Conf Ser. 61: 643–6. Bibcode:2007JPhCS..61..643K. doi:10.1088/1742-6596/61/1/129. 
  9. ^ The Housekeeper's Almanac, or, the Young Wife's Oracle! for 1840!. No. 134. New-York: Elton, 1840. Print.
  10. ^ http://www.newscientist.com/article/dn1475-mummymaking-complexity-revealed.html#.VKVwGMksoow
  11. ^ Tips for Cabinet Making Shops
  12. ^ Nasrallah, Nawal (2007). Annals of the Caliphs' Kitchens: Ibn Sayyâr al-Warrâq's Tenth-century Baghdadi Cookbook. Islamic History and Civilization, 70. Leiden, The Netherlands: Brill. ISBN 978-0-415-35059-4. 
  13. ^ a b An Anonymous Andalusian cookbook of the 13th century, translated from the original Arabic by Charles Perry
  14. ^ Titley, Norah M. (2004). The Ni'matnama Manuscript of the Sultans of Mandu: The Sultan's Book of Delights. Routledge Studies in South Asia. London, UK: Routledge. ISBN 978-0-415-35059-4. 
  15. ^ [Quran 76:5]
  16. ^ Moqrich, A.; Hwang, Sun Wook; Earley, Taryn J.; Petrus, Matt J.; Murray, Amber N.; Spencer, Kathryn S. R.; Andahazy, Mary; Story, Gina M.; Patapoutian, Ardem (2005). "Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin". Science 307 (5714): 1468–72. Bibcode:2005Sci...307.1468M. PMID 15746429. doi:10.1126/science.1108609. 
  17. ^ Green, B. G. (1990). "Sensory characteristics of camphor". The Journal of investigative dermatology 94 (5): 662–6. PMID 2324522. 
  18. ^ Lääketietokeskus. Lääkevalmisteet Pharmaca Fennica 1996, p. 814.
  19. ^ Miller, Charles. History of Sumatra : An account of Sumatra. p. 121. 
  20. ^ Pearce, J.M.S. (2008). "Leopold Auenbrugger: Camphor-Induced Epilepsy – Remedy for Manic Psychosis". European Neurology 59 (1–2): 105–7. PMID 17934285. doi:10.1159/000109581. 
  21. ^ Bayes (1866). "Cholera, as Treated by Dr. Rubini". The American Homoeopathic Review 6 (11–12): 401–3. 
  22. ^ Church, John (1797). An inaugural dissertation on camphor: submitted to the examination of the Rev. John Ewing, S.S.T.P. provost ; the trustees & medical faculty of the University of Pennsylvania, on the 12th of May, 1797 ; for the degree of Doctor of Medicine. University of Philadelphia: Printed by John Thompson. Retrieved January 18, 2013. 
  23. ^ Moqrich, A.; Hwang, Sun Wook; Earley, Taryn J.; Petrus, Matt J.; Murray, Amber N.; Spencer, Kathryn S. R.; Andahazy, Mary; Story, Gina M.; Patapoutian, Ardem (2005). "Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin". Science 307 (5714): 1468–72. Bibcode:2005Sci...307.1468M. PMID 15746429. doi:10.1126/science.1108609. 
  24. ^ Green, B. G. (1990). "Sensory characteristics of camphor". The Journal of investigative dermatology 94 (5): 662–6. PMID 2324522. 
  25. ^ "Camphor overdose". Medline. NIH. Retrieved January 19, 2012. 
  26. ^ Martin D, Valdez J, Boren J, Mayersohn M (Oct 2004). "Dermal absorption of camphor, menthol, and methyl salicylate in humans". Journal of Clinical Pharmacology 44 (10): 1151–7. PMID 15342616. doi:10.1177/0091270004268409. 
  27. ^ Uc A, Bishop WP, Sanders KD (Jun 2000). "Camphor hepatotoxicity". Southern Medical Journal 93 (6): 596–8. PMID 10881777. doi:10.1097/00007611-200006000-00011. 
  28. ^ "Poisons Information Monograph: Camphor". International Programme on Chemical Safety. 

External links

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