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Carbamoyl phosphate

Carbamoyl phosphate
Structural formula
Ball-and-stick model
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IUPAC name
(Carbamoyloxy)phosphonic acid
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590-55-6 7pxY
ChEBI CHEBI:17672 7pxN
ChEMBL ChEMBL369105 7pxN
ChemSpider 272 7pxN
Jmol-3D images Image
KEGG C00169 7pxN
MeSH Carbamoyl+phosphate
PubChem Template:Chembox PubChem/format
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CH2NO5P2−
Molar mass 141.020 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines.

Production

It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

  • HCO3 + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
  • HO–C(O)–OPO32− + NH3 + OH → HPO42− + O–C(O)NH2 + H2O
  • O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−

See also

References

  • Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York. 

Template:Nucleotide metabolism intermediates Template:Urea cycle

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