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Carboxycyclophosphamide

Carboxycyclophosphamide
Carboxycyclophosphamide chemical structure
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IUPAC name
3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid
Other names
Carboxyphosphamide
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22788-18-7
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C7H15Cl2N2O4P
Molar mass 293.084762
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).[1]

References


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