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Open Access Articles- Top Results for Carmofur

Carmofur

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Carmofur
File:Carmofur.svg
Systematic (IUPAC) name
5-fluoro-N-hexyl-2,4-dioxo-pyrimidine-1-carboxamide
Clinical data
AHFS/Drugs.com International Drug Names
Oral
Identifiers
61422-45-5 7pxY
L01BC04
PubChem CID 2577
DrugBank DB09010 7pxN
ChemSpider 2479 7pxN
UNII HA82M3RAB2 7pxN
ChEMBL CHEMBL460499 7pxN
Synonyms 1-hexylcarbamoyl-5-fluorouracil
Chemical data
Formula C11H16FN3O3
257.261 g/mol
 14pxN (what is this?)  (verify)

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.

Mechanism of action

Uses

Breast Cancer

Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.[1]

Adverse effects

As fluorouracil, carmofur has been known to induce leukoencephalopathy.[2][3][4]

References

  1. ^ Sakamoto, J; Hamada, C; Rahman, M; Kodaira, S; Ito, K; Nakazato, H; Ohashi, Y; Yasutomi, M (2005). "An Individual Patient Data Meta-analysis of Adjuvant Therapy with Carmofur in Patients with Curatively Resected Colon Cancer". Japanese Journal of Clinical Oncology 35 (9): 536–544. PMID 16155120. doi:10.1093/jjco/hyi147. 
  2. ^ Yamada T, Okamura S, Okazaki T et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature". Asia Oceania J Obstet Gynaecol 15 (2): 161–8. PMID 2667512. 
  3. ^ Mizutani T (February 2008). "[Leukoencephalopathy caused by antineoplastic drugs]". Brain Nerve (in Japanese) 60 (2): 137–41. PMID 18306661. 
  4. ^ Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients". J Neurol Neurosurg Psychiatr 79 (5): 535–9. PMID 17682013. doi:10.1136/jnnp.2007.123737. 

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