Open Access Articles- Top Results for CatSper2


External IDsOMIM607249 MGI2387404 HomoloGene77423 IUPHAR: 389 GeneCards: CATSPER2 Gene
RefSeq (mRNA)NM_172095NM_153075
RefSeq (protein)NM_054020NP_694715
Location (UCSC)Chr 15:
41.71 – 41.75 Mb
Chr 2:
121.22 – 121.24 Mb
PubMed search[1][2]

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[1][2] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[3]


Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[4]


  1. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. PMC 60087. PMID 11675491. doi:10.1073/pnas.221454998. 
  2. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. PMID 16382101. doi:10.1124/pr.57.4.7. 
  3. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  4. ^ "Entrez Gene: CatSper2". 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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