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Open Access Articles- Top Results for Cathepsin A

Cathepsin A

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Identifiers
SymbolsCTSA ; GLB2; GSL; NGBE; PPCA; PPGB
External IDsOMIM613111 MGI97748 HomoloGene80163 IUPHAR: 1581 ChEMBL: 6115 GeneCards: CTSA Gene
EC number3.4.16.5
RNA expression pattern
File:PBB GE CTSA 200661 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez547619025
EnsemblENSG00000064601ENSMUSG00000017760
UniProtP10619P16675
RefSeq (mRNA)NM_000308NM_001038492
RefSeq (protein)NP_000299NP_001033581
Location (UCSC)Chr 20:
44.52 – 44.53 Mb
Chr 2:
164.83 – 164.84 Mb
PubMed search[1][2]

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.[1]

Function

This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.[2]

Clinical significance

Deficiencies in this gene are linked to multiple forms of galactosialidosis.[1]

Interactions

Cathepsin A has been shown to interact with NEU1.[3]

References

  1. ^ a b "Entrez Gene: CTSA cathepsin A". 
  2. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Robbins, Stanley L.; Abbas, Abul K.; Fausto, Nelson (2007). "Table 7-6". Robbins basic pathology (8th ed.). Saunders/Elsevier. ISBN 1-4160-2973-7. 
  3. ^ van der Spoel, A; Bonten E; d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A". EMBO J. (ENGLAND) 17 (6): 1588–97. ISSN 0261-4189. PMC 1170506. PMID 9501080. doi:10.1093/emboj/17.6.1588. 

Further reading

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External links


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