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Cathine, also known as d-norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which acts as a stimulant. Along with cathinone, it is found naturally in Catha edulis (khat), and contributes to its overall effects. It has approximately 10-14% the potency of amphetamine.
Like amphetamines, cathinone, and ephedrine, cathine acts as a releasing agent of norepinephrine and epinephrine, or as a norepinephrine releasing agent (NRA). It also acts as a dopamine releasing agent (DRA) to a lesser extent.
The World Anti-Doping Agency's list of prohibited substances (used for the Olympic Games among other athletic events) bars cathine in concentrations of over 5 micrograms per milliliter in urine. Cathine is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance.
- L-Norpseudoephedrine, an enantiomer
- Catha Edulis ("Khat")
- Ephedra Sinica ("Ephedra")
- Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves.. Toennes SW, et al. (2003 Jul). Retrieved on 2014-01-31.
- Hoffman, R; Al'Absi, M (December 2010). "Khat use and neurobehavioral functions: suggestions for future studies." (PDF). Journal of Ethnopharmacology 132 (3): 554–63. PMC 2976806. PMID 20553832. doi:10.1016/j.jep.2010.05.033.
- "List of psychotropic substances under international control" (PDF). International Narcotics Control Board. Archived from the original (PDF) on 2012-08-31.