Cation channels of sperm
|cation channel, sperm associated 1|
|Locus||Chr. 11 q12.1|
|cation channel, sperm associated 2|
|Locus||Chr. 15 q13-q15|
|cation channel, sperm associated 3|
|Locus||Chr. 5 q31.2|
|cation channel, sperm associated 4|
|Locus||Chr. 1 p35.3|
The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.
- Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. PMC 1770895. PMID 17227845. doi:10.1073/pnas.0610286104.
- CATSPER1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GeneReviews/NCBI/NIH/UW entry on CATSPER-Related Male Infertility
- "CatSper and Two-Pore Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.