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Celiprolol

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Celiprolol
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Systematic (IUPAC) name
(RS)-N'-{3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N,N-diethylurea
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Bioavailability 30-70%
Half-life 5 hours
Identifiers
56980-93-9
C07AB08
PubChem CID 2663
ChemSpider 2563
UNII DRB57K47QC 7pxY
KEGG D07660
ChEMBL CHEMBL27810
Chemical data
Formula C20H33N3O4
379.49 g/mol

Celiprolol (brand names Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.

A recent clinical trial has suggested a use for this medication in the prevention of vascular complications of a rare inherited disease called vascular Ehlers–Danlos syndrome. This study demonstrated decreased incidence of arterial rupture or dissection (a specific type of arterial rupture in which the layers of the vessel separate prior to complete failure of the artery wall).[1]

References

  1. ^ Ong K-T et al. (2010). "Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial". Lancet 376 (9751): 1476–1484. PMID 20825986. doi:10.1016/S0140-6736(10)60960-9. 

External links

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