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Open Access Articles- Top Results for Ceritinib

Ceritinib

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Ceritinib
File:Ceritinib.svg
Systematic (IUPAC) name
5-Chloro-N2-[2-isopropoxy-5-methyl-4-(4-piperidinyl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]-2,4-pyrimidinediamine
Clinical data
Trade names Zykadia
Identifiers
1032900-25-6
L01XE28
PubChem CID 57379345
ChemSpider 29315053
ChEBI CHEBI:78432
ChEMBL CHEMBL2403108
Synonyms LDK378
Chemical data
Formula C28H36ClN5O3S
558.14 g/mol

Ceritinib (trade name Zykadia) is a drug for the treatment of lung cancer.[1] It is an ALK inhibitor.[2] It was approved in April 2014 by the Food and Drug Administration for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) following treatment with crizotinib.[1]

References

  1. ^ a b "FDA Approves Ceritinib for ALK-Positive Lung Cancer". Medscape. April 29, 2014. 
  2. ^ Shaw AT, Kim DW, Mehra R, Tan DS, Felip E, Chow LQ, Camidge DR, Vansteenkiste J, Sharma S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A, Lau YY, Goldwasser M, Boral AL, Engelman JA (2014). "Ceritinib in ALK-Rearranged Non–Small-Cell Lung Cancer". N Engl J Med 370: 1189–1197. PMID 24670165. doi:10.1056/NEJMoa1311107. 


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