Open Access Articles- Top Results for Charles Brenton Huggins

Charles Brenton Huggins

"Charles Huggins" redirects here. For the politician, see Charlie Huggins.
Charles Brenton Huggins
Charles Brenton Huggins
Born (1901-09-22)September 22, 1901
Halifax, Nova Scotia
Died January 12, 1997(1997-01-12) (aged 95)
Chicago, Illinois
Citizenship American
Fields physiology
Institutions University of Chicago
Alma mater Acadia University
Harvard University
Doctoral advisor Template:If empty
Known for prostate cancer
Notable awards Nobel Prize for Physiology or Medicine (1966)
Gairdner Foundation International Award (1966)

Charles Brenton Huggins (September 22, 1901 – January 12, 1997) was a Canadian-born American physician, physiologist and cancer researcher at the University of Chicago specializing in prostate cancer. He was awarded the 1966 Nobel Prize for Physiology or Medicine for discovering in 1941 that hormones could be used to control the spread of some cancers.[1] This was the first discovery that showed that cancer could be controlled by chemicals.

Early life and education

Huggins was born in Halifax, Nova Scotia, Canada. He graduated from Acadia University with a BA degree in 1920. He went on to study medicine at Harvard University and received his MD degree in 1924.


Higgins established a method to measure the effect hormone changes have on prostatic function. He found out that castration or estrogen administration led to glandular atrophy, which could be reversed by re-administration of androgen. In 1941 the beneficial effect of androgen ablation on metastatic prostate cancer was realised when Huggins and Clarence Hodges treated patients by either castration or estrogen therapy. They monitored the prostate size and therapeutic efficacy by measuring serum Prostatic acid phosphatase levels and concluded that androgenic activity in the body influences prostate cancer, at least with respect to serum phosphatase. Huggins was the first to use a systemic approach to treat prostate cancer.

Huggins was awarded the Nobel Prize in Physiology or Medicine in 1966.[2]

Huggins died 1997 in Chicago, Illinois at the age of 95 years. His wife died in 1983.


  1. Huggins C, Hodges CV (2002). "Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.". The Journal of Urology 167 (2): 948–951. PMID 11905923. doi:10.1097/00005392-200207000-00004. 
  2. Denmeade, SR; Isaacs, JT (May 2002). "A history of prostate cancer treatment.". Nature reviews. Cancer 2 (5): 389–96. PMID 12044015. doi:10.1038/nrc801. 
  • Toledo-Pereyra, L H (2001). "Discovery in surgical investigation: the essence of Charles Brenton Huggins". Journal of investigative surgery : the official journal of the Academy of Surgical Research 14 (5): 251–2. PMID 11700917. doi:10.1080/089419301753170011. 
  • Forster, R E (June 1999). "Charles Brenton Huggins (22 September 1901–12 January 1997)". Proceedings of the American Philosophical Society 143 (2): 325–31. PMID 11623829. 
  • Raju, T N (August 1999). "The Nobel chronicles. 1966: Francis Peyton Rous (1879–1970) and Charles Brenton Huggins (1901–97)". Lancet 354 (9177): 520. PMID 10465213. doi:10.1016/S0140-6736(05)75563-X. 
  • Schmähl, D (1980). "[Charles Brenton Huggins, Nobel Prize for Medicine 1966: "Discovery is our business"]". Chirurgisches Forum für experimentelle und klinische Forschung: VI–VIII. PMID 6993114. 
  • Drucker, W R (1973). "Charles B. Huggins, MD, FACS (hon)". Surgical forum 24: V. PMID 4618632. 
  • "Classics in oncology. Charles Brenton Huggins". CA: a cancer journal for clinicians 22 (4): 230–1. 1972. PMID 4625048. doi:10.3322/canjclin.22.4.230. 
  • Kenéz, J (October 1971). "[Ch. B. Huggins at the age of 70]". Orvosi hetilap 112 (42): 2535–7. PMID 4943846. 
  • Morii, S (May 1971). "[My professor, Dr. Huggins]". Hinyokika kiyo. Acta urologica Japonica 17 (5): 295–6. PMID 4933515. 
  • Fukunishi, R (October 1967). "[Pioneer of cancer research: Dr. Charles B. Huggins]". Nippon Rinsho 25 (8): 1709–12. PMID 4868962. 
  • Schmähl, D (December 1966). "[Charles Brenton Huggins]". Dtsch. Med. Wochenschr. 91 (51): 2308–9. PMID 5333371. 
  • Frenkel, M (November 1966). "[Charles Brenton Huggins, co-winner of the Nobel Prize in physiology and medicine, 1966]". Nederlands tijdschrift voor geneeskunde 110 (45): 1994–5. PMID 5342106. 
  • Luft, R (November 1966). "[Nobel prize in physiology and medicine 1966. Charles Brenton Huggins]". Nordisk medicin 76 (44): 1269–71. PMID 5337055. 
  • Franksson, C (October 1966). "[Nobel Prize of the year. II. Charles B. Huggins]". Lakartidningen 63 (43): 4102–4. PMID 5343069. 
  • TALALAY, P (June 1965). "The Scientific Contributions Of Charles Brenton Huggins". JAMA 192: 1137–40. PMID 14301033. doi:10.1001/jama.1965.03080260025007. 

External links

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