Open Access Articles- Top Results for Chlormadinone acetate

Chlormadinone acetate

Chlormadinone acetate
File:Chlormadinone acetate.svg
Systematic (IUPAC) name
(8ξ,10ξ,13ξ,17α)-6-chloro-3,20-dioxopregn-4-en-17-yl acetate
Clinical data
  • (Prescription only)
Pharmacokinetic data
Half-life 34-38 hours
PubChem CID 9324
ChemSpider 8963
Chemical data
Formula C23H29ClO4
404.92696 g/mol

Chlormadinone acetate (INN, USAN, BAN, JAN; sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton, and many others), sometimes abbreviated as CMA, and also known as 17α-acetoxy-6-chloro-6-dehydroprogesterone, is a steroidal progestin with additional antiandrogen and antigonadotropic (and thus also antiestrogenic) effects.[1][2][3][4] It is used clinically as a hormonal contraceptive, and in part due to its lowering of estrogen levels, but also for improved effectiveness in contraception, chlormadinone is frequently combined with ethinyl estradiol for this purpose.[5] It is the acetate ester of chlormadinone.[1][2]

See also


  1. ^ a b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012. 
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012. 
  3. ^ Raudrant D, Rabe T (2003). "Progestogens with antiandrogenic properties". Drugs 63 (5): 463–92. PMID 12600226. doi:10.2165/00003495-200363050-00003. 
  4. ^ Chassard D, Schatz B (2005). "[The antigonadrotropic activity of chlormadinone acetate in reproductive women]". Gynécologie, Obstétrique & Fertilité (in French) 33 (1-2): 29–34. PMID 15752663. doi:10.1016/j.gyobfe.2004.12.002. 
  5. ^ Bouchard P (2005). "Chlormadinone acetate (CMA) in oral contraception--a new opportunity". The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception. 10 Suppl 1: 7–11. PMID 16356876. doi:10.1080/13625180500434889.