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Chlorphentermine

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Chlorphentermine
File:Chlorphentermine.svg
Systematic (IUPAC) name
1-(4-chlorophenyl)-2-methylpropan-2-amine
Clinical data
  • Schedule III (US)
Oral, Insufflated, Rectal
Pharmacokinetic data
Half-life 40 hours
Excretion Renal
Identifiers
461-78-9 7pxN 151-06-4
A08AA
PubChem CID 10007
DrugBank DB01556 7pxY
ChemSpider 9613 7pxY
UNII NHW07912O7 7pxY
KEGG C07559 7pxY
ChEMBL CHEMBL1201269 7pxN
Synonyms p-Chloro-α,α-dimethylphenethylamine
Chemical data
Formula C10H14ClN
183.68 g/mol
 14pxN (what is this?)  (verify)

Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is an appetite suppressant of the phenethylamine class. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,[1] which is still in current use.

Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule III drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.[2]

See also

References

  1. ^ Gylys JA, Hart JJ, Warren MR. Chlorphentermine, a new anorectic agent. Journal of Pharmacology and Experimental Therapeutics. 1962 Sep;137:365-73.
  2. ^ Rothman RB, Ayestas MA, Dersch CM, Baumann MH. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75.