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Chlorproethazine

Chlorproethazine
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This page is a soft redirect. Names

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IUPAC name
3-(2-chlorophenothiazin-10-yl)-N,N-diethylpropan-1-amine
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ATC code N05AA07
84-01-5 7pxY
4611-02-3 7pxN
ChEMBL ChEMBL2105938 7pxN
ChemSpider 59173 7pxN
Jmol-3D images Image
KEGG D07308 7pxY
PubChem Template:Chembox PubChem/formatTemplate:Chembox PubChem/format
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C19H23ClN2S
Molar mass 346.91732 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Chlorproethazine is an antipsychotic.

Synthesis

Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps.

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Thus alkylation of aniline thioether () with 3-chloro-1-diethylaminopropane leads to the intermediate (). Ring closure as above by nucleophilic aromatic displacement leads to the antipsychotic drug chlorproethazine.[1]

References

  1. ^ Buisson, P.; Gailliot, P.; 1956, U.S. Patent 2,769,002



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