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Open Access Articles- Top Results for Chlortetracycline

Chlortetracycline

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Chlortetracycline
File:Chlortetracycline.svg
File:Chlortetracycline-3D-balls.png
Systematic (IUPAC) name
(4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Oral, IV, topical
Pharmacokinetic data
Bioavailability 30%
Protein binding 50 to 55%
Metabolism Hepatic (75%)
Half-life 5.6 to 9 hours
Excretion Renal and biliary
Identifiers
57-62-5 7pxY
A01AB21 D06AA02 J01AA03 S01AA02 QG51AA08 QJ51AA03
ChemSpider 10469370 7pxY
UNII WCK1KIQ23Q 7pxY
KEGG D07689 7pxY
ChEMBL CHEMBL456066 7pxN
Chemical data
Formula C22H23ClN2O8
478.88 g/mol
 14pxN (what is this?)  (verify)

Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.

In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]

References

  1. ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
  2. ^ Merck Veterinary Manual. 


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