Open Access Articles- Top Results for Chorioamnionitis


Micrograph showing chorioamnionitis. The clusters of blue dots are inflammatory cells (neutrophils, eosinophils and lymphocytes). H&E stain.
Classification and external resources
ICD-10 O41.1, P02.7
ICD-9 658.4, 762.7
DiseasesDB 31882
eMedicine ped/89
NCI Chorioamnionitis
Patient UK Chorioamnionitis
MeSH D002821

Chorioamnionitis also known as intra-amniotic infection (IAI)[1] is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. It typically results from bacteria ascending into the uterus from the vagina and is most often associated with prolonged labor. The risk of developing chorioamnionitis increases with each vaginal examination that is performed in the final month of pregnancy, including during labor.[3]


The fetal membranes consist of two parts:

  • The outer membrane is the chorion. It is closest to the mother and physically supports the much thinner amnion.
  • The inner membrane is the amnion. It is in direct contact with the amniotic fluid, which surrounds the fetus.


File:Chorioamnionitis - intermed mag.jpg
Intermediate magnification micrograph of moderate chorioamnionitis. H&E stain.


Chorioamnionitis is diagnosed clinically in the setting of Maternal fever (≥100.4º F) and at least two of the following: [2]

  • Maternal leukocytosis (>15,000cells/mm3)
  • Maternal tachycardia (>100bpm)
  • Fetal tachycardia (>160bpm)
  • Uterine tenderness
  • Foul odor of amniotic fluid[3]



Chorioamnionitis can be diagnosed from a histologic examination of the fetal membranes.

Infiltration of the chorionic plate by neutrophils is diagnostic of (mild) chorioamnionitis. More severe chorioamnionitis involves subamniotic tissue and may have fetal membrane necrosis and/or abscess formation.

Severe chorioamnionitis may be accompanied by vasculitis of the umbilical blood vessels (due to the fetus' inflammatory cells) and, if very severe, funisitis (inflammation of the umbilical cord's connective tissue).


Antibiotic Treatment consists of:

  • Standard: Ampicillin 2g IV every 6 hours + Gentamicin 1.5mg/kg every 8 hours
  • Alternative: Ampicillin-Sulbactam 3g IV every 5 hours, Ticarcillin-Clavulanate 3.1g IV every 4 hours, Cefoxitine 2g IV every 6 hours
  • Cesarean Delivery: Ampicillin 2g IV every 6 hours + Gentamicin 1.5mg/kg every 8 hours + Clindamycin 900mg every 8 hours or Metronidazole 500mg IV every 6 hours
  • Penicillin-Allergy: Vancomycin 1g IV every 12 hours + Gentamicin 1.5mg/kg every 8 hours

Completion of treatment/cure is only considered after delivery of the infected products of conception.



Chorioamnionitis is a risk factor for periventricular leukomalacia and cerebral palsy.[5]

See also


  1. ^ "Intra–Amniotic Infection". Retrieved 20 December 2014. 
  2. ^ Elmar Peter Sakala, MD, MA, MPH, FACOG. Professor of GYNOB, Loma Linda University of medicine, California. Codirector of Student Clerkship. Dept of GYNOB
  3. ^
  4. ^
  5. ^ Wu YW, Colford JM (2000). "Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis". JAMA 284 (11): 1417–24. PMID 10989405. doi:10.1001/jama.284.11.1417. 


  • Excess Digital Exams Raise Risk of Chorioamnionitis, Ob.Gyn. News, August 15, 1997
  • Centers for disease control and prevention (2002) Prevention of perinatal group B Streptococcal disease: revised guidelines from CDC. MMWR 51:RR-11:1–28

External links