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Cicletanine

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Cicletanine
File:Cycletanide.png
Systematic (IUPAC) name
3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
Clinical data
AHFS/Drugs.com International Drug Names
Oral
Pharmacokinetic data
Protein binding 97.3%
Half-life 7.9 h
Identifiers
89943-82-8
C03BX03
PubChem CID 54910
ChemSpider 49583 7pxY
UNII CHG7QC509W 7pxY
KEGG D03487 7pxY
ChEMBL CHEMBL191886 7pxY
Chemical data
Formula C14H12ClNO2
261.703 g/mol
 14pxY (what is this?)  (verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.[2]

Mechanism

It can inhibit protein kinase C.[3]

References

  1. ^ Jean Sassard (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 978-0-86196-313-3. 
  2. ^ Bagrov AY; Dmitrieva RI; Dorofeeva NA et al. (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". J. Hypertens. 18 (2): 209–15. PMID 10694190. doi:10.1097/00004872-200018020-00012. 
  3. ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension 41 (3): 505–11. PMID 12623951. doi:10.1161/01.HYP.0000053446.43894.9F. 

External links


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