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Cilastatin

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Cilastatin
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Systematic (IUPAC) name
(Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a686013
IV
Identifiers
82009-34-5 7pxY
J01DH51 (combination with imipenem)
PubChem CID 5280454
DrugBank DB01597 7pxY
ChemSpider 4940183 7pxY
UNII 141A6AMN38 7pxY
KEGG D07698 7pxY
ChEBI CHEBI:3697 7pxY
ChEMBL CHEMBL766 7pxY
Chemical data
Formula C16H26N2O5S
358.454 g/mol
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Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]

Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity.

Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

See also

References

  1. ^ Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ (1995). "The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA". Antimicrob. Agents Chemother. 39 (7): 1629–31. PMC 162797. PMID 7492120. doi:10.1128/aac.39.7.1629.