Open Access Articles- Top Results for Cinchocaine


File:Cinchocaine 3D ball-and-stick.png
Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
topical, intravenous (equine euthanasia)
85-79-0 7pxY
C05AD04 D04AB02 N01BB06 S01HA06 S02DA04
PubChem CID 3025
DrugBank DB00527 7pxY
ChemSpider 2917 7pxY
KEGG D00733 7pxY
ChEBI CHEBI:247956 7pxY
Chemical data
Formula C20H29N3O2
343.463 g/mol
 14pxY (what is this?)  (verify)

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Medical use

Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

Physical properties

Cinchocaine is relatively insoluble in alkaline aquatic solutions.

See also


  1. Martindale, The Extra Pharmacopoeia, 30th ed, p1006
  2. Dibucaine

Further reading

  • Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco 60 (5): 419–24. PMID 15910814. doi:10.1016/j.farmac.2005.03.001. 
  • Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res 99 (4): 317–20. PMID 16612626. doi:10.1007/s00436-006-0192-1. 
  • Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm 62 (5): 369–79. PMID 16459486. 
  • Aroti,A.;Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment .". Journal of Chemical Education 78 (6): 786–788. doi:10.1021/ed078p786. 

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