Open Access Articles- Top Results for Cinitapride


Systematic (IUPAC) name
Clinical data
  • (Prescription only)
66564-14-5 7pxY
PubChem CID 68867
DrugBank DB08810 7pxY
ChemSpider 62099 7pxY
UNII R8I97I2L24 7pxY
KEGG D07700 7pxY
Chemical data
Formula C21H30N4O4
402.49 g/mol
 14pxY (what is this?)  (verify)

Cinitapride (Cintapro, Pemix) is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain.[1][2] It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.[3][4]


It is indicated for the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.

See also


  1. ^ Robert M, Salvà M, Segarra R et al. (July 2007). "The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole". Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (7): 1149–56. PMID 17437965. doi:10.1124/dmd.106.010835. 
  2. ^ Fernández AG, Massingham R (January 1985). "Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs". Life Sciences 36 (1): 1–14. PMID 2981378. doi:10.1016/0024-3205(85)90280-2. 
  3. ^ Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V (April 1997). "Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds". Pharmacology 54 (4): 193–202. PMID 9211565. doi:10.1159/000139487. 
  4. ^ Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V (March 1998). "Effects of cinitapride on gastric ulceration and secretion in rats". Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.] 47 (3): 131–6. PMID 9562338. doi:10.1007/s000110050301. 

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