Frequent Links
Cirazoline
200px | ||
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other This page is a soft redirect. Names #REDIRECTmw:Help:Magic words#Other |
IUPAC name
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
| |
---|---|---|
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other This page is a soft redirect. Identifiers#REDIRECTmw:Help:Magic words#Other This page is a soft redirect.-
|
59939-16-1 7px | |
ChEMBL | ChEMBL13852 7px | |
ChemSpider | 2663 7px | |
IUPHAR ligand | 515 | |
Jmol-3D images | Image | |
MeSH | cirazoline | |
PubChem | Template:Chembox PubChem/format | |
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other This page is a soft redirect. Properties #REDIRECTmw:Help:Magic words#Other |
C13H16N2O | |
Molar mass | 216.279 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | ||
14px verify (what is: 10px /10px ?) | ||
Infobox references | ||
Cirazoline is a full agonist at the alpha-1A (α1A) adrenergic receptor, a partial agonist at both the alpha-1B (α1B) adrenergic receptor and alpha-1D (α1D) adrenergic receptor,[1] and a nonselective antagonist to the alpha-2 adrenergic receptor.[2] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[2]
Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[3]
References
- ^ Horie, K; Obika, K; Foglar, R. (1995). "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypes". British Journal of Pharmacology 116 (1): 1611–8. PMID 8564227. doi:10.1111/j.1476-5381.1995.tb16381.x.
- ^ a b Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist and an α2 adrenergic antagonist". Journal of Pharmacology and Experimental Therapeutics 222 (1): 29–36. PMID 6123592.
- ^ Davies, B. T.; Wellman, P. J. (1992). "Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline". European Journal of Pharmacology 210 (1): 11–16. PMID 1350985. doi:10.1016/0014-2999(92)90645-K.
Lua error in package.lua at line 80: module 'Module:Buffer' not found.