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Open Access Articles- Top Results for Cloroqualone

Cloroqualone

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Cloroqualone
200px
Systematic (IUPAC) name
3-(2,6-Dichlorophenyl)-2-ethyl-4-quinazolinone
Clinical data
  •  ?
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Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half-life ?
Excretion ?
Identifiers
25509-07-3 7pxN
None
PubChem CID 63338
DrugBank ? 7pxN
ChemSpider 57005 7pxY
UNII 172D4Q6LOW 7pxY
ChEMBL CHEMBL2106114 7pxN
Chemical data
Formula C16H12Cl2N2O
319.185
 14pxN (what is this?)  (verify)

Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.

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