Open Access Articles- Top Results for Cloxacillin


File:Cloxacillin ball-and-stick.png
Systematic (IUPAC) name
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
Trade names Cloxapen
AHFS/ Micromedex Detailed Consumer Information
  • US: B (No risk in non-human studies)
Oral, IM
Pharmacokinetic data
Bioavailability 37 to 90%
Protein binding 95%
Half-life 30 minutes to 1 hour
Excretion Renal and biliary
61-72-3 7pxY
J01CF02 QJ51CF02 QS01AA90
PubChem CID 6098
DrugBank DB01147 7pxY
ChemSpider 5873 7pxY
KEGG D07733 7pxY
ChEBI CHEBI:49566 7pxY
Chemical data
Formula C19H18ClN3O5S
435.88 g/mol
 14pxY (what is this?)  (verify)

Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections. It is semisynthetic and in the same class as penicillin.

Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind. This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.

Cloxacillin was discovered and developed by Beecham.[1] It is sold under a number of trade names, including Cloxapen, Cloxacap, Tegopen and Orbenin. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[2]

See also


  1. ^ David Greenwood (2008). Antimicrobial drugs: chronicle of a twentieth century medical triumph. Oxford University Press US. pp. 124–. ISBN 978-0-19-953484-5. Retrieved 18 November 2010. 
  2. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 

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