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Collagen, type XXVII, alpha 1

Template:PBB/85301 Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene.[1]

COL27A1 is a type XXVII collagen. It was discovered by James Pace.[2] This gene appears to be turned on in cartilage, the eye, and in the ear. Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton.

Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form major structural elements in extracellular matrices of cartilage, skin, and tendon.[1][3]


  1. ^ a b "Entrez Gene: collagen". 
  2. ^ Pace JM, Corrado M, Missero C, Byers PH (March 2003). "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1". Matrix Biol. 22 (1): 3–14. PMID 12714037. doi:10.1016/S0945-053X(03)00007-6. 
  3. ^ Boot-Handford RP, Tuckwell DS, Plumb DA, Rock CF, Poulsom R (August 2003). "A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family". J. Biol. Chem. 278 (33): 31067–77. PMID 12766169. doi:10.1074/jbc.M212889200. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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