Adverts

Open Access Articles- Top Results for Complement component 2

Complement component 2

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsC2 ; ARMD14; CO2
External IDsOMIM613927 MGI88226 HomoloGene45 GeneCards: C2 Gene
EC number3.4.21.43
RNA expression pattern
File:PBB GE C2 203052 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez71712263
EnsemblENSG00000166278ENSMUSG00000024371
UniProtP06681P21180
RefSeq (mRNA)NM_000063NM_013484
RefSeq (protein)NP_000054NP_038512
Location (UCSC)Chr 6:
31.87 – 31.91 Mb
Chr 17:
34.86 – 34.9 Mb
PubMed search[1][2]

Complement C2 is a protein that in humans is encoded by the C2 gene.[1] The protein encoded by this gene is part of the classical pathway of complement system.

In the "classical" pathway of complement activation, activated C1 cleaves C4a and C4b, and cleaves C2 into C2a and C2b. The complex of the large fragments of C2 and C4, called C4b2a, is the classical C3 convertase and can activate C3. Deficiency of C2 has been associated with certain autoimmune diseases.[1]

References

Further reading

</dl>

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.