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Complement factor B

SymbolsCFB ; AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2
External IDsOMIM138470 MGI105975 HomoloGene1292 IUPHAR: 2339 ChEMBL: 5731 GeneCards: CFB Gene
EC number3.4.21.47
RNA expression pattern
File:PBB GE CFB 202357 s at tn.png
File:PBB GE CFB 211920 at tn.png
More reference expression data
RefSeq (mRNA)NM_001710NM_001142706
RefSeq (protein)NP_001701NP_001136178
Location (UCSC)Chr 6:
31.9 – 31.92 Mb
Chr 17:
34.86 – 34.86 Mb
PubMed search[1][2]
File:Droga alternatywna.png
Alternative pathway. (Some labels are in Polish.)

Complement factor B is a protein that in humans is encoded by the CFB gene.[1]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[1]

Complement tests
C4 (C) FB (A) C3 CH50 Conditions
 · PSG, C3 NeF AA
 ·  · HA, C4D
 ·  ·  · TCPD
 · /↓ SLE


Further reading


External links

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