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A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.
Defects in these receptors can be associated with disease.