Open Access Articles- Top Results for Congenital rubella syndrome

Congenital rubella syndrome

Congenital rubella syndrome
File:Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores.jpg
White pupils due to congenital cataract in a child with congenital rubella syndrome
Classification and external resources
ICD-10 P35.0
ICD-9 771.0
DiseasesDB 11729
MedlinePlus 001658
eMedicine emerg/388
NCI Congenital rubella syndrome
Patient UK Congenital rubella syndrome
MeSH D012410

Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted rubella, usually in the first trimester. If infection occurs 0–28 days before conception, the infant has a 43% chance of being affected. If the infection occurs 0–12 weeks after conception, the chance increases to 51%. If the infection occurs 13–26 weeks after conception, the chance is 23% of the infant being affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.

It was discovered in 1941 by Australian Norman McAlister Gregg.[1]

Signs and symptom

File:Infant with skin lesions from congenital rubella.jpg
Infant with skin lesions from congenital rubella
File:Congenital Rubella Syndrome, Salt and Pepper Retinopathy.jpg
"Salt-and-pepper" retinopathy is characteristic of congenital rubella.[2]
File:Rubella serology.png
Congenital rubella serology time-line

The classic triad for congenital rubella syndrome is:

Other manifestations of CRS may include:

Children who have been exposed to rubella in the womb should also be watched closely as they age for any indication of:


Vaccinating the majority of the population is effective at preventing congenital rubella syndrome.[6]


  1. ^ Atkinson, William (2011). Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). Public Health Foundation. pp. 301–323. ISBN 9780983263135. Retrieved Mar 2015. 
  2. ^ Sudharshan S, Ganesh SK, Biswas J (2010). "Current approach in the diagnosis and management of posterior uveitis". Indian J Ophthalmol 58 (1): 29. ISSN 0301-4738. PMID 20029144. doi:10.4103/0301-4738.58470. 
  3. ^ Oster ME, Riehle-Colarusso T, Correa A (January 2010). "An update on cardiovascular malformations in congenital rubella syndrome.". Clin Mol Teratol. 88 (1): 1–8. PMID 19697432. doi:10.1002/bdra.20621. 
  4. ^ Muhle, R; Trentacoste, SV; Rapin, I (May 2004). "The genetics of autism.". Pediatrics 113 (5): e472–86. PMID 15121991. doi:10.1542/peds.113.5.e472. 
  5. ^ Brown, A. S (9 February 2006). "Prenatal Infection as a Risk Factor for Schizophrenia". Schizophrenia Bulletin 32 (2): 200–202. PMC 2632220. PMID 16469941. doi:10.1093/schbul/sbj052. 
  6. ^ "Rubella vaccines: WHO position paper." (PDF). Wkly Epidemiol Rec 86 (29): 301–16. 15 July 2011. PMID 21766537. 

External links