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Crotamiton

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Crotamiton
File:Crotamiton.png
Systematic (IUPAC) name
(E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide[1]
Clinical data
AHFS/Drugs.com monograph
Identifiers
483-63-6 7pxY
QP53AX04
PubChem CID 688020
DrugBank DB00265 7pxY
ChemSpider 599515 7pxY
UNII D6S4O4XD0H 7pxY
KEGG D01381 7pxY
ChEMBL CHEMBL1200709 7pxN
Chemical data
Formula C13H17NO
203.28 g/mol
 14pxN (what is this?)  (verify)

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.

Use

For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24-hour delay in between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.

Pharmacology

The mechanism of action of crotamiton is unknown,however it is toxic to the scabies mite.[2]

Pharmacokinetics

After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.[3]

Side effects

The most common side effect of crotamiton is skin irritation.

Trade name

Crotamiton is marketed under the trade names Eurax, which is manufactured by Ranbaxy Laboratories in the USA, and Novartis in the UK, and Euracin, which is manufactured by Green Cross in South Korea. In Germany, it is marketed under the brand name, Crotamitex. In India it's sold as Eurax by Ranbaxy Laboratories

References