Open Access Articles- Top Results for Cullen%27s sign

Cullen's sign

Cullen's sign
Cullen's sign
DiseasesDB 17313

Cullen's sign is superficial edema and bruising in the subcutaneous fatty tissue around the umbilicus.

It is named for Thomas Stephen Cullen (1869–1953),[1] gynecologist who first described the sign in ruptured ectopic pregnancy in 1916.[2]

This sign takes 24–48 hours to appear and can predict acute pancreatitis, with mortality rising from 8–10% to 40%. It may be accompanied by Grey Turner's sign[3] (bruising of the flank), which may then be indicative of pancreatic necrosis with retroperitoneal or intraabdominal bleeding.


Causes include:

Importance of the sign is on a decline since better diagnostic modalities are now available.


  1. ^ synd/1386 at Who Named It?
  2. ^ E. Cullen. Embryology, anatomy, and diseases of the umbilicus together with diseases of the urachus. Philadelphia, Saunders, and London, 1916.
  3. ^ Bosmann M, Schreiner O, Galle PR (April 2009). "Coexistence of Cullen's and Grey Turner's signs in acute pancreatitis". Am. J. Med. 122 (4): 333–4. PMID 19332225. doi:10.1016/j.amjmed.2008.08.032. 

Parikh RP, Upadhyay KJ. Cullen's sign for acute haemorrhagic pancreatitis. Indian J Med Res [serial online] 2013 [cited 2013 Jul 4];137:1210

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