Open Access Articles- Top Results for Cutis laxa

Cutis laxa

Cutis laxa
Classification and external resources
ICD-10 L57.4, Q82.8 (ILDS Q82.816)
ICD-9 701.8, 756.83
OMIM 123700 219100 219200 304150
DiseasesDB 29439
eMedicine derm/03
NCI Cutis laxa
Patient UK Cutis laxa
MeSH D003483
"Dermatochalasia" redirects here. For the medical condition affecting eyelids, see Dermatochalasis.

Cutis laxa (also known as Chalazoderma, Dermatochalasia, Dermatolysis, Dermatomegaly, Generalized elastolysis, Generalized elastorrhexis,[1] or Pachydermatocele[2]) is a group of rare connective tissue disorders in which the skin becomes inelastic and hangs loosely in folds.


In most cases, cutis laxa is inherited. Autosomal dominant, autosomal recessive and X-linked recessive forms have been described, but acquired forms also occur.

In patients suffering from cutis laxa, mutations in the elastic fibers comprising the dermis have been identified.

Cutis laxa may be caused by mutations in the genes: ELN,[3] ATP6V0A2,[4] ATP7A,[5]FBLN4,[6] FBLN5,[7] and PYCR1.[8] A related neurocutaneous syndrome may be caused by mutations in the gene ALDH18A1 aka P5CS.[9]


It is characterized by skin that is loose, hanging, wrinkled, and lacking in elasticity. The loose skin is often most noticeable on the face, resulting in a prematurely aged appearance. The affected areas of skin may be thickened and dark. In addition, the joints are loose (hypermobility) because of lax ligaments and tendons. When cutis laxa is severe, it can also affect the internal organs. The lungs, heart (supravalvular pulmonary stenosis), intestines, or arteries may be affected with a variety of severe impairments. In some cases, hernias and outpouching of the bladder can be observed. Patients also present with blue sclera.

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