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Cysteinyl leukotriene receptor 1

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Identifiers
SymbolsCYSLTR1 ; CYSLT1; CYSLT1R; CYSLTR; HMTMF81
External IDsOMIM300201 MGI1926218 HomoloGene4837 IUPHAR: 269 ChEMBL: 1798 GeneCards: CYSLTR1 Gene
Orthologs
SpeciesHumanMouse
Entrez1080058861
EnsemblENSG00000173198ENSMUSG00000052821
UniProtQ9Y271Q99JA4
RefSeq (mRNA)NM_001282186NM_001281859
RefSeq (protein)NP_001269115NP_001268788
Location (UCSC)Chr X:
77.53 – 77.58 Mb
Chr X:
106.57 – 106.6 Mb
PubMed search[1][2]

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system.[4] Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[3]

See also

References

  1. ^ Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). "Characterization of the human cysteinyl leukotriene CysLT1 receptor". Nature 399 (6738): 789–93. PMID 10391245. doi:10.1038/21658. 
  2. ^ Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor". Mol Pharmacol 56 (3): 657–63. PMID 10462554. 
  3. ^ a b "Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1". 
  4. ^ . UniProt Consortium http://www.uniprot.org/uniprot/Q9Y271.  Missing or empty |title= (help)

External links

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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