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Open Access Articles- Top Results for Cytidine

Cytidine

Not to be confused with cytosine, cysteine, cystine, or cytisine.
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Cytidine
Skeletal formula of cytidine
Ball-and-stick model of the cytidine molecule
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IUPAC name
4-​amino-​1-​[3,​4-​dihydroxy-​5-​(hydroxymethyl)​tetrahydrofuran-​2-​yl]​pyrimidin-​2-​one
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65-46-3 7pxY
ChEBI CHEBI:17562 7pxY
ChEMBL ChEMBL95606 7pxY
ChemSpider 5940 7pxY
Jmol-3D images Image
KEGG D07769 7pxY
MeSH Cytidine
PubChem Template:Chembox PubChem/format
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C9H13N3O5
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA.

If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine.

Dietary sources of cytidine

Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content,[1] such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact.[1] In humans, dietary cytidine is converted into uridine,[2] which is probably the compound behind cytidine's metabolic effects.

Cytidine analogs

There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen,[3] and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.[4]

References

  1. ^ a b Jonas DA; Elmadfa I; Engel KH et al. (2001). "Safety considerations of DNA in food". Ann Nutr Metab. 45 (6): 235–54. PMID 11786646. doi:10.1159/000046734. 
  2. ^ Wurtman RJ, Regan M, Ulus I, Yu L (Oct 2000). "Effect of oral CDP-choline on plasma choline and uridine levels in humans". Biochem Pharmacol. 60 (7): 989–92. PMID 10974208. doi:10.1016/S0006-2952(00)00436-6. 
  3. ^ John S. James. "New Kind of Antiretroviral, KP-1461". AIDS Treatment News. 
  4. ^ "Scientists reprogram cancer cells with low doses of epigenetic drugs". Medical XPress. March 22, 2012. 

External links